The Lotto-Belisol rider sustained a knee injury in a mass pile-up inside the final 200 metres of Wednesday's stage.
Aix En Provence, France Belgian rider Jurgen Van den Broeck became the first high-profile casualty of this year's Tour de France when he pulled out injured before the sixth stage.
The rider's team Lotto-Belisol confirmed the news on Thursday.
A spokesman for the team told Reuters by telephone that Van den Broeck, fourth overall in last year's race, sustained a knee injury in a mass pile-up inside the final 200 metres of Wednesday's stage.
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